Addison is not prepared for all the changes that greet her upon her return to Seattle Grace for a specialized surgery, Meredith and Derek begin their clinical trial, Izzie feels left out, and Karev is confronted with an unexpected announcement.

Starring:

Ellen Pompeo, Chandra Wilson, James Pickens, Jr., Justin Chambers, Sara Ramirez, Patrick Dempsey, Kevin McKidd, Sandra Oh, Jessica Capshaw, Jesse Williams, Sarah Drew, Eric Dane, Camilla Luddington, Katherine Heigl, Chyler Leigh, Jerrika Hinton, T.R. Knight, Jason George, Caterina Scorsone, Kelly McCreary, Isaiah Washington, Kim Raver, Kate Walsh, Giacomo Gianniotti, Martin Henderson, Gaius Charles, Tessa Ferrer, Brooke Smith, Jake Borelli, Greg Germann, Chris Carmack, Richard Flood, Anthony Hill

Genre:

Drama, Romance, Medical